Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

"Our work provides exciting new insights into the mechanism of minor intron recognition and sheds light on the evolution of the splicing machinery.

They also observed that intron retention decreased gene expression. The researchers investigated the effect of a splicing mutant on intron retention and gene expression. They observed that while ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...

During splicing, the spliceosome assembles on the pre-mRNA molecule and brings together the donor site at the 5' end of the intron and the acceptor site at the 3' end of the intron.

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are ...

His lab slowed the splicing process in yeast cells, and discovered that after the spliceosome released the mRNA that it had finished splicing introns from, it hung onto intron lariats and reshaped ...

During splicing, the spliceosome assembles on the pre-mRNA molecule and brings together the donor site at the 5' end of the intron and the acceptor site at the 3' end of the intron.

Pre-tRNA is converted into mature tRNA, which has a complex 3D structure, through a series of steps, including the excision of an intron by specific endonucleases. In humans, this is catalyzed by the ...

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.