Quality assurance in the cell: Preventing defective protein blueprints
Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...
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Nature10d
RNA splicing articles from across Nature Portfolio
Non-viral intron knock-ins for incorporating synthetic exons into endogenous introns enable efficient gene targeting and selective gene knockout in successfully edited cells. Proper splicing ...
eLife3y
Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation
Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors. Type I PRMT enzymes catalyze mono- and asymmetric dimethylation; Type II enzymes catalyze mono- ...
eLife4y
The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
Moreover, SFPQ depletion leads to increased intron retention with concomitant induction of cryptic splicing, premature transcription termination, and polyadenylation, particularly prevalent for long ...