Once amyloid pathology is underway, it predicts intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles and that, in turn, predicts onset of cognitive impairment.

Discover the breakthrough Alzheimer's test that measures tau tangles in blood, simplifying Alzheimer's diagnosis and ...

The brains of patients with Alzheimer's disease are characterized by the abundance of extracellular amyloid plaques and intracellular neurofibrillary tangles. The major constituent of the amyloid ...

In neurodegenerative disorders, chemical changes in the brain cause tau proteins to detach and start to clump together, forming what are known as neurofibrillary tangles. These tangles disrupt the ...