Collaborative research led by investigators at Dana-Farber/Boston Children's Cancer and Blood Disorders Center defines a novel approach to understanding how certain proteins called transcription ...

Researchers harness the power of the world’s most advanced supercomputers to simulate the inner workings of cellular ...

Multi-epitope immunopurifications of huntingtin (HTT) from vulnerable brain regions of Huntington’s disease (HD) models ...

by generating lethal DNA breaks during by transcription-coupled NER. Selection of Et743-resistant cell lines We generated two Et743-resistant derivatives of human colon carcinoma cells.

The researchers then measured the repair of oxidative DNA damage by analyzing levels of a marker known as 8-hydroxy-2′-deoxyguanosine (8-OH-dG) in urine samples. Higher levels of this marker ...

Instead, long-lasting epigenetic differences between trained and non-trained cells are always coupled with changes in transcription factor (TF) activity, emphasizing the central role played by TFs, ...

Here, we show that density gradient purified sEVs (1.06–1.11 g/ml, Alix + and TSG101 +, ∼180 nm) from human endometrial epithelial cells ... performed on a Dionex UltiMate NCS-3500RS nanoUHPLC coupled ...

Dynamic regulation of transcription is crucial for the cellular responses ... yet its cellular functions and regulatory circuits remain unclear. Here, we show that human GDOWN1 strictly localizes in ...

Transcription-coupled repair (TCR) is a sub-pathway of nucleotide excision repair (NER) that preferentially removes lesions from the template-strand (t-strand) that stall RNA polymerase (RNAP) ...