A team led by Professor Kazuhiro Maeshima of the National Institute of Genetics (ROIS) and SOKENDAI in Japan has developed a ...

The “Histones and Chromatin” Review series published in EMBO Reports and The EMBO Journal includes six reviews centered around the histone code hypothesis. The reviews focus on histone variants and ...

Atomic force microscopy images show hepatitis B DNA in its natural state (left) and a zoomed-in look at how it wraps around human histones during an infection (right). The research team determined ...

To clarify the association between certain immunologic factors and clinical activity in patients with systemic lupus erythematosus, 96 patients were studied. Those with antibodies to ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Researchers at Fred Hutch Cancer Center have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly ...

Hepatitis B virus (HBV) affects 300 million people worldwide and is a major driver of liver diseases. But while decades of research have led to vaccines, antivirals, and a better understanding of the ...

Gene expression is regulated by transcription factors in concert with epigenetic modifications (such as DNA methylation, post-translational histone modifications, the position and compaction of ...

The basic pattern of genomic DNA methylation is established at the time of embryo implantation through a wave of de novo methylation, but CpG islands are protected through a mechanism that ...

The organization of genomes in space and time dimension plays an important role in gene expression and regulation. Chromatin folding occurs in a dynamic, structured way that is subject to biophysical ...

Eukaryotes have four major families of chromatin remodelers: SWI/SNF, ISWI, CHD, and INO80 (Clapier and Cairns, 2009). Each of these remodelers plays distinct roles based on how they select and affect ...