Transgenic worm in which the splicing factor UNC-75, marked with the fluorophore mScarlet, reveals its expression throughout the nervous system. The worm was generated using CRISPR-Cas9 gene editing ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing.

Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often distinguishing between cell types more accurately than gene expression. 1 During ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity.

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

This produces the mature mRNA that contains the instructions for making a protein for a specific gene. Because incorrect RNA splicing can result in dysfunctional or overactive proteins ...