The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

The virus condenses and changes the shape of our genetic material to hijack the host genes needed ... the compaction — that links between chromosomes might be severed, for example — but that’s not the ...

The latest evidence suggests that LPA gene splicing affects lipoprotein(a) concentration. The splice variant 4925 G>A is associated with low‐molecular‐weight apolipoprotein(a) isoforms and has been ...

(A) The RNA-overhang cloning method. The parental genes (top) are the human AMPA glutamate receptor GluR2 intron 14 and its flanking exons (this gene is shown twice: lines 1 and 3), and the human ...

Genomic research holds incredible promise for improving human health, but one major challenge has slowed its progress: ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

BARCELONA, Spain, June 11, 2025 /PRNewswire/ -- SpliceBio, a clinical-stage genetic medicines company pioneering Protein Splicing to address diseases caused by mutations in large genes, today ...

SB-007 is an investigational Protein Splicing dual AAV gene therapy in development for the treatment of Stargardt disease. It is designed to restore expression of the native full-length ABCA4 ...

BARCELONA, Spain, June 11, 2025 /PRNewswire/ -- SpliceBio, a clinical-stage genetic medicines company pioneering Protein Splicing to address diseases caused by mutations in large genes, today ...

QIMR Berghofer scientists, in collaboration with the Valladolid University (Spain), have published two groundbreaking studies that advance the understanding of RNA splicing in the TP53 gene, the gene ...

Panelists discuss how splice modifiers work by enhancing protein production from the SMN2 gene, with risdiplam (Evrysdi) being an oral daily medication and nusinersen (Spinraza) being administered ...