This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the phosphodiester bond at the 3′ splice site. The adjoining exons are covalently bound ...

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

Overriding the "Off Switch" Cells function through an intricate network of proteins, each designed for specific tasks like ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Scientists reveal how cancer cells manipulate RNA splicing, increasing tumor growth. A new study introduces antisense ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

Alternative splicing adds an extra layer of complexity, because regulatory sequences that sometimes designate an exon's inclusion into the mature mRNA dictate the exclusion of that exon under ...

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Breakthrough discovery in cancer research! Scientists uncover a simple genetic strategy to combat aggressive cancers. Learn ...

to restore poison exon activity, the team effectively reactivated this kill switch, offering a potential new precision therapy for aggressive, hard-to-treat cancers. Alternative RNA splicing is ...