Eukaryotes possess promoter and termination regions that are largely nucleosome free. Nucleosomes are positioned at canonical distances from the transcription start site (TSS). In Saccharomyces ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research Colin W. Hay; Kevin Docherty Disclosures Diabetes. 2006;55 (12):3201-3213. 0 ...

Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research Colin W. Hay; Kevin Docherty Disclosures Diabetes. 2006;55 (12):3201-3213. 0 ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins ... by inositol metabolism enzymes serve as vital secondary messengers in eukaryotic cell signaling ...

The mediator complex is essential for the initiation of eukaryotic gene transcription (Thompson and Young, 1995; Myers et al, 1998) and is highly conserved across eukaryotes (Bourbon, 2008). It ...