Enhancers can be thousands of nucleotides away from the promoters with which they interact, but they are brought into proximity by the looping of DNA. This looping is the result of interactions ...

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the “enhancer” DNA switches that turn them on ...

Enhancers were formerly believed to be modular. Each enhancer occupies a separate region of DNA, as the term suggests. “We have shown, however, that this is not absolutely true," explained ...

Transcriptional enhancers are short regions of DNA that, when bound by proteins, increase the likelihood that a particular gene will be transcribed. They are therefore essential for controlling gene ...

Researchers used powerful technology to analyse thousands of individual cells at once, considering which genes are active.

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the “enhancer” DNA switches that turn them on ...

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the "enhancer" DNA switches that turn them ...

After TFs bind to promoter or enhancer regions of the DNA, they interact with other bound TFs and recruit RNA polymerase II. Their influence, however, can be either positive or negative ...