Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is ...

Understanding enhancer function is very important, since they contain the majority of genetic variants ('mutations') associated with common diseases, such as autoimmune, metabolic and neurological ...

This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...

MaizeCODE is a genomic project analyzing the genetic basis of maize domestication. Researchers identified key regulatory ...

CSHL Professors Thomas Gingeras and Rob Martienssen have launched a new genomic encyclopedia called MaizeCODE. Their latest ...

In a 2010 Nature paper, researchers in the lab of neurobiologist Michael Greenberg at Harvard Medical School reported that enhancers can produce RNA. Working with cultured mouse neurons, the ...

“We didn’t think it would work.” The results serve as an extreme example of what scientists are now recognizing as trends among enhancers—that activity can be conserved over long evolutionary ...

Understanding enhancer function is very important, since they contain the majority of genetic variants (‘mutations’) associated with common diseases, such as autoimmune, metabolic and neurological ...

By poring over DNA sequences of zebrafish and human enhancers, the team noticed that only some of them were conserved, whereas others had largely non-conserved genetic code. Sequence-conserved ...