In a groundbreaking advancement for families grappling with the challenges of Dravet syndrome, a rare and life-altering form ...

By replacing the defective gene associated with Dravet syndrome in mice, scientists successfully alleviated symptoms without side effects.

Snakes are one of the most dangerous yet fascinating reptiles. With their stunning patterns, slithering noises and poisonous ...

which allows for greater flexibility in the control of gene expression. As previously mentioned, enhancer sequences are DNA sequences that are bound by an activator protein, and they can be ...

Some of these “enhancers” regulatory sequences function similarly to the dimmer switches that control the lighting in the living room. In fact, when and where a specific gene is needed ...

An international collaboration of researchers led by Masahito Yoshihara at Chiba University (Japan) has identified novel transcriptional enhancers that regulate gene expression in neuronal development ...

In a 2010 Nature paper, researchers in the lab of neurobiologist Michael Greenberg at Harvard Medical School reported that enhancers can produce RNA. Working with cultured mouse neurons, the ...

Two other groups had previously used CRISPR to create knockout libraries of protein-coding genes in human cells for functional genetic screens. But the current work is the first genetic screen of ...

Researchers used powerful technology to analyse thousands of individual cells at once, considering which genes are active.

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

Researchers develop a novel Tle6 gene hetero knockout mice model to understand the role of this gene in male fertility and find that its deficiency results in abnormal sperm structure, reduced ...