Hosted on MSN20d
Synthesis method unlocks a pathway to valuable fluorinated drug compounds for new medicines
In this vein, isosteric replacement of a CH 2 unit within an oxetane (or C=O group within a β-lactone) with CF 2 results in α,α-difluoro-oxetanes, a prized class of heterocyclic compounds with ...
Hosted on MSN17d
Novel Catalysis Yields Elusive Fluorinated Oxetanes for Drug Discovery
Specifically, replacing a CH2 group in oxetanes (or a C=O in β-lactones) with a CF2 unit produces α,α-difluoro-oxetanes. These α,α-difluoro-oxetanes uniquely combine the advantages of small ...
Armed robbery in Revesby20d
New Technique Yields Key Fluorinated Drug Compounds
In this vein, isosteric replacement of a CH 2 unit within an oxetane (or C=O group within a β-lactone) with CF 2 results in α,α-difluoro-oxetanes, a prized class of heterocyclic compounds with ...
C&EN18d
Carrier-Free Cisplatin–Dactolisib Nanoparticles for Enhanced Synergistic Antitumor Efficacy
School of Engineering, Institute for Materials and Processes, University of Edinburgh, Robert Stevenson Road, Edinburgh EH9 3FB, U.K. School of Engineering, Institute for Bioengineering, University of ...
C&EN2d
Green-Solvent-Processed All-Polymer Solar Cells with Enhanced Efficiency and Stability through Molecular Design and Side-Chain Engineering
Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China ...