The RNA quality control machinery directs the degradation ... mediated mRNA decay (NMD), during cellular senescence and its impact on NMD efficiency, leading to the accumulation of aberrant ...

From treating neurodegenerative diseases and cancer care to pioneering mRNA and macrophage therapy ... a protein associated with disease onset or progression, targeted protein degradation (TPD) ...

PINK1 accumulates at the surface of damaged mitochondria when the constitutive degradation of PINK in the mitochondrial ... These POLRMT mutations induce a defect in mitochondrial mRNA synthesis but ...

Table 01: Global Nucleic Acid Therapeutics Market Value (US$ Mn) Forecast, By Therapy Type, 2020 - 2035 Table 02: Global Nucleic Acid Therapeutics Market Value (US$ Mn) Forecast, By Delivery Method, ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Following the COVID-19 pandemic, mRNA-based vaccines have been shown to provide rapid and precise immune responses, however, this technology has much wider applications. Many leading pharma and ...

Another Friday night, another Trump administration purge. This time the targets included two of the nation’s top military leaders and, nearly as troubling, the top lawyers for the Army, Navy ...

Opinion articles provide independent perspectives on key community issues, separate from our newsroom reporting. I’ve been speaking, protesting and writing books and articles about the threat to ...

GSK has upgraded its longstanding alliance with CureVac on mRNA-based vaccines for respiratory infections, paying €400 million ($429 million) upfront for global rights to its influenza and COVID ...