In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...

Nucleoside analogs are transformative in cancer and antiviral therapies, offering new avenues for treatment despite ...

Each of the two strands of the DNA molecule acts as a template for the synthesis ... role of this protein in maintaining the balance between mitochondrial transcription and replication.

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

This intricate system of DNA replication, protein synthesis and cellular processes—all based on long strings of molecules linked by carbon atoms—is fundamental to life on Earth. However, the universe ...

or Rad17–replication factor C (RFC), could be used as 'bait' to capture additional polymerases involved in TLS or in specialized DNA synthesis. Many of these protein–protein associations ...

Cancer cells display high levels of oncogene-induced replication stress (RS ... act synergistically to prevent the proliferation of cancer cells, by inhibiting DNA synthesis and by impeding the ...

Metabolomic analysis demonstrated compensatory metabolic adjustments affecting protein synthesis and DNA replication in the resistant strain. These findings provide insights into the complex ...

Northwestern Medicine scientists have uncovered new details explaining how poxviruses manipulate host cells to enhance their own protein ... and form large DNA-filled replication compartments.

"Successful self-replication under no human assistance is the essential step for AI to outsmart [humans], and is an early signal for rogue AIs," the researchers wrote in the study, published Dec ...

New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic ...

State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei 430061, PR China ...