it is possible to optimize the values in the PWM such that the probability of binding to the known binding sites (versus the more abundant background DNA) is maximized. The optimal weight matrix ...

We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the lands where we live, learn and work.

Classically, quantitative geneticists have envisioned DNA sequence variants as the only source of heritable phenotypes. This view should be revised in light of accumulating evidence for widespread ...