Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

The findings are published in the journal Current Biology in an article titled, “Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor ...

The spliceosome is composed of 5 filaments of RNA and hundreds of proteins. Among these elements, the researchers have discovered that, in yeast, the Spp42 protein ...

These components hail from nuclear speckles—the membraneless organelles that house the spliceosome. Tau fibrils not only disrupted speckle organization, but also snatched pieces from them and made off ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...

The spliceosome, a protein-RNA complex, catalyzes the splicing reaction by removing introns, a specific type of nucleotide sequence, from cellular messenger RNA transcripts (Figure 1).

How the cell protects itself Researchers discover the mechanism that prevents damage caused by shortened proteins Date: June 12, 2019 Source: University of Göttingen ...