The spliceosome, which forms on introns, is composed of proteins and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 ...

We characterized back-splicing cis- and trans-elements, and found viral circRNAs resistant to spliceosome perturbation and lacking canonical splice donor-acceptors. Subsequent loss-of-function studies ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Plant arbovirus infection is regulated by a ...

This was achieved by deleting the initial GU dinucleotide sequence at the 5’ end of the intron, which is required for the binding of the U1 protein of the spliceosome. Imaging and biochemical ...

1 The importance of these processes in the pathogenesis of TDP-43 proteinopathies requires further clarification. Cytoplasmic aggregation of TDP-43 has also been demonstrated in glial cells,47 48 ...

Erythroblasts possess unique characteristics as they undergo differentiation from hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large amounts of iron in order to ...

Background: Cystic fibrosis (CF) is a common monogenic multisystem disease caused primarily by variants in the CFTR gene. Emerging evidence suggests that some variants, which are described as missense ...

The sections were then stained with eosin for 10-15 s to highlight cytoplasmic components. Finally, the slides were dehydrated through a graded ethanol series (95% and 100%), cleared in xylene, and ...

Department of Chemistry and Biochemistry, Humboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Greinstrasse 4-6, 50939 Cologne, Germany ...