eLife26d
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Representative conformations of rapamycin were identified by clustering ... (C-D) A zoom-in on the binding site shows the hydrogen bond between the hydroxyl group on the cyclohexane ring in rapamycin ...
C&EN28d
Hydrogen Borrowing Catalysis for the Modification, Depolymerization, and Synthesis of Polyesters
Determined by gel permeation chromatography (GPC) in THF. The oligomer formation was neglected. b M/C/B is the utilized number of ester groups (M) to base (B) and precatalyst (C) ratio. The reactions ...
C&EN17d
Excited-State Aromatization Drives Nonequilibrium Planarization Dynamics
Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science, National Institutes of Natural Sciences, 38 Nishigo-Naka, Myodaiji, Okazaki 444-8585, Japan Graduate ...
eLife26d
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
The hydroxyl group on carbon 40 within the cyclohexane ring in rapamycin is indispensable for activation, while other rapalogs with its replacement, such as everolimus, still bind but cannot activate ...
The EMBO Journal22d
Kick-starting the zygotic genome: licensors, specifiers, and beyond
This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...