New Cryptic Exon. Compared to UNC13A splicing in control iPSC-derived neurons (teal), the transcript in cells with TDP-43 knocked down (gold) harbored a cryptic exon. Single-nucleotide polymorphisms ...

Pseudo splice sites and cryptic splicing “The human genome has introns that are significantly longer than exons. These long introns contain numerous small segments, called pseudo splice sites, that ...

More information: Cristian Prieto-Garcia et al, Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination ...

Within exon 2a of the STMN2 gene, TDP-43 binds between a cryptic splice initiation site and a cryptic poly-A motif. The five ASOs that best squelched cryptic SMN2 splicing bind around the TDP-43 site.

New cryptic splice variants and SNVs in PLCg1 gene of Alzheimer's disease (AD)-specific models for the first time using Splice-AI have been discovered by Korea Brain Research Institute (KBRI ...

Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD ...

If pseudo splice sites are used instead of the correct splice sites during protein synthesis, the resulting mRNA will contain the wrong instructions – cryptic splicing – that could alter ...

They looked into splice sites, the segments that mark the location for the splicing of exons. Pseudo splice sites and cryptic splicing “The human genome has introns that are significantly longer ...

hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing. Molecular Cell , 2024; DOI: 10.1016/j.molcel.2024.05.004 Cite This Page : ...