A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team.

Article Title Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy.

Researchers in the U.K. have succeeded in reverse engineering the defective cryptic splicing that drives amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) to enable precisely ...

This important paper addresses the process by which cryptic splice sites that occur randomly in exons are ignored by the splicing machinery. Integrating state-of- the-art genome-wide approaches such ...

We propose RBMX family proteins are particularly important for the splicing inclusion of some ultra-long exons with increased intrinsic susceptibility to cryptic splice site selection. eLife ...

If pseudo splice sites are used instead of the correct splice sites during protein synthesis, the resulting mRNA will contain the wrong instructions – cryptic splicing – that could alter ...

The team also discovered that in the absence of hnRNPM, cryptic splicing can form double stranded RNA (dsRNA), which is known to trigger interferon immune responses.

The researchers discovered that despite the presence of many pseudo splice sites, RNA splicing occurs accurately and precisely thanks to the RNA-binding protein hnRNPM. They discovered this by ...

Results Three novel APC variants were identified in six families and were shown to cause aberrant splicing because of the creation of a deep intronic cryptic splice site that leads to an RNA ...