Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary ...

Bile duct inflammation and scarring, known as cholangiopathies, can disrupt bile flow, leading to liver damage and ...

More than 1,000 different drugs are thought to cause liver damage and one French study estimated the global annual incidence rate of drug-related liver damage as 8 cases per 100,000 inhabitants ...

Here’s what a team of experts discovered. This rare syndrome, marked by too few bile ducts resulting in cholestasis, can damage not only the liver and heart but the eyes as well. According to ...

Chemomab's OLE study of nebokitug in PSC patients confirmed safety and showed improvements in liver stiffness, fibrosis ...

Speculations are based on the clinical and biochemical findings in FIC1 disease patients ... which could trigger cholestasis. Interestingly, sweat sodium concentrations are markedly increased ...

influencing the liver’s niche and disease outcomes. Here the authors show that in response to bile acid chenodeoxycholic acid during cholestasis, endothelial Myc activation triggers P-selectin ...

and progressive familial intrahepatic cholestasis (PFIC) Prevention and Management Adopting a healthy lifestyle is crucial to reduce the risk of liver disease in adulthood. Avoiding alcohol ...

Mirum and Takeda entered into an exclusive license agreement in September 2021 for the development and commercialization of LIVMARLI for rare cholestatic pediatric liver diseases in Japan.