Medscape15d
Prenatal Diagnosis of Progressive Familial Intrahepatic Cholestasis Type 2
Background and Aim:Progressive familial intrahepatic cholestasis type 2 (PFIC2) results from genetic defects of the hepatobiliary bile salt export pump (BSEP, ABCB11) at chromosome 2q24.
The New England Journal of Medicine18d
Benign Postoperative Intrahepatic Cholestasis
The clinical picture and course in all these cases were associated with histologic evidence of intrahepatic cholestasis. Only patients with clinical evidence of jaundice and a serum bilirubin ...
C&EN26d
Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury
Available assays at Bayer for two of the endpoints (Bile salt export pump (BSEP) inhibition and phospholipidosis) were run on a set of public compounds and used for further evaluation (data provided ...
Medscape23y
FIC1 Disease: A Spectrum of Intrahepatic Cholestatic Disorders
FIC1 deficiency would then lead to ionic imbalance within hepatocytes, which could trigger cholestasis. Interestingly, sweat sodium concentrations are markedly increased in some PFIC1 patients.