News & Views Published: February 2008 Regulating rejection with cell therapy Mohamed H Sayegh & Howard L Weiner Nature Biotechnology 26, 191–192 (2008) Cite this article ...

In the BM3 RAG-1 −/− × CBK system the trigger for massive local inflammation and complement activation is completely defined and consists of a single T cell fetal alloantigen and a single ...

alloantigen - individual HLA/MHC peptides that recruit recipient T cells the vast number of T cell clones recruited to the response antigen presentation by donor APCs (direct antigen presentation ...

Using sugar-coated proteins to trick the immune system in heart transplants Targeting recipient antigen-presenting cells with sialic acid-modified alloantigen to promote transplantation tolerance ...

By contrast, the fourth patient, who had previously displayed but lost operational tolerance, had a strong alloantigen-specific trans-vivo DTH response. [26] ...

This book is written as a comprehensive guide for all tissue bank operators to procure and process bone and soft tissue allografts of highest quality standards for safe tissue transplantation practice ...

Application of anti-CD48 mAb can effectively restrain not only weak, hapten-specific responses, but also strong, alloantigen-specific responses of cytotoxic T lymphocytes (CTLs) in vivo (95). Besides, ...

Optimization of the systems for active-targeting drug delivery is a pending task in view of more directed transport of the active components to neoplastic cells. One of the ways to improved ...

A 35-year-old man presented with polyarthritis and constitutional symptoms, and a recent history of multiple tick bites and skin rash on trekking holiday. He did not respond to oral doxycycline and ...

In the lung, CD103+ DCs acquire and process cell-associated viral antigens, migrate to the mediastinal lymph nodes, and cross-present these antigens to CD8+ T cells during influenza A virus infection ...