However, it is often complicated by alloantigen-induced immune activation, a response triggered by the donor’s immune system against recipient antigens and/or the recipient's immune system against ...

Besides the pivotal role played by alloantigen-specific T cells and antibodies in the pathogenesis of graft rejection, natural killer (NK) cells alloreactivity and their contribution to antiviral ...

Bone-marrow-derived multipotent progenitor stromal cells — or mesenchymal stem cells (MSCs) — are the common predecessors of cells of the mesenchymal lineage, such as bone, cartilage and fat ...

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States Siteman Cancer Center, Washington University School of Medicine, St Louis, United ...

This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC Class I allele, can lead to NK cell licensing, thereby providing ...

Objective Accumulation of mitochondria underlies T-cell dysfunction in systemic lupus erythematosus (SLE). Mitochondrial turnover involves endosomal traffic regulated by HRES-1/Rab4, a small GTPase ...

Correspondence to Professor Gabriela Riemekasten, Department of Rheumatology, University Hospital Schleswig-Holstein—Campus Lübeck, Ratzeburger Allee 160, Lübeck 23538, Germany; ...