Eli Lilly is further expanding its RNA medicine strategy by tapping South Korea’s Rznomics for a $1.3 billion biobucks deal focused on treating hearing loss. The centerpiece of the agreement is ...

Fred Hutch and MSK researchers showed that tumors driven by hiccups in RNA processing can't hid from the immune system. In work published in Cell, the team showed they could isolate T cells that ...

Fig. 1: Development of DRAM system for m 5 C detection. (A) Schematic diagram of the DRAM assay. DRAM, DRAM mut and Deaminase system were transfected into HEK293T cells separately. After DRAM ...

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...

By designing gRNAs to target these specific sites, CRISPR-Cas9 can be utilized to introduce precise modifications and manipulate splicing. Following CRISPR-Cas9 treatment, RNA-Seq can be performed to ...

RNA splicing ribozymes have been shown to possess a conserved active site that can engage small molecules, opening possibilities for the control of gene expression.

A technique that enables scientists to record gene mutations and patterns of gene activity in individual cells has been extended to cover RNA splicing as well, in a study led by researchers at Weill ...

They argue that since aberrant splicing dysregulation occurs commonly in neurodegenerative disease, the promise of using RNA therapies is important to understand and well-suited for a review.

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability.