RNA splicing requires the spliceosome, whose formation involves a complex interplay of trans-acting factors, including five small nuclear ribonucleoprotein particles (snRNPs): U1, U2, U4/U6, and U5 ...

Chimeric RNAs: RNA molecules formed by the fusion of sequences from different genes, which can result from gene fusions or splicing events. Trans-splicing: A process where exons from two different ...

Lady Gaga took center stage at the Grammys after winning the award for best pop duo/group performance and sent a message of support to trans people in her acceptance speech. “It’s such an ...

But it didn’t stop there. This deliberate rollback of trans and other LGBTQ+ rights and protections also includes a section with definitions that belies basic biology: claiming that “‘female ...

Transcriptional regulation governs gene expression levels, primarily controlled by “cis-acting DNA elements” and “trans-acting protein factors ... the expression of immune molecule 7SL RNA. In summary ...

In her waning days as assistant secretary for health at the Department of Health and Human Services, Rachel Levine thinks back fondly to attending a 2022 Pride Month reception at the White House.

Writer Jenny Boylan is perplexed about why trans people “finding their peace” has resulted in such outrage from much of the American public. She moves forward in the only way she knows how ...

Follow our ongoing coverage for further updates. Under normal conditions, there’s a standard order of operations for trans people updating their identity documents. It begins with securing a ...

What Does It Mean to Be Trans? Transgender is a general term that describes people whose gender identity, or their internal sense of being male, female, or something else, does not match the sex ...

This important study addresses the idea that defective lysosomal clearance might be causal to renal dysfunction in cystinosis. With mostly solid data, the authors observe that restoring expression of ...

Lentiviruses were packaged in HEK-293T cells using the second-generation packaging system plasmid psPAX2 (Addgene) and pMD2.G (Addgene ... Nuclei were stained with DAPI (Thermo Fisher Scientific). RNA ...