Furthermore, researchers must exercise caution with respect to the specificity of any given mRNA-targeting approach, whether ASO, RNAi, trans-splicing, or ribozyme based, to ensure that only the ...

Many diseases arise through splicing errors, in which mutated genes give rise to primary RNA ... designed ASO can overcome this. “You’re using them to mask critical regions on an mRNA that ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target tumor growth and restore cellular regulation.

Dyne Therapeutics’ DYNE-101 shows positive results in phase 1/2 ACHIEVE study. Read why DYN stock may rise with FDA approval and a $2.78B market opportunity.

This RNA, called an antisense oligonucleotide (ASO), was so effective ... The ASO prevented the splicing factor from binding to the TEAD mRNA, so it couldn't ultimately splice it out.

Overriding the "Off Switch" Cells function through an intricate network of proteins, each designed for specific tasks like ...