Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...

Natural "off switch" could slow or even reverse the growth of aggressive tumors.

Emerging evidence suggests that some variants, which are described as missense, synonymous or nonsense variants in the literature or databases, may be deleterious by affecting the pre-mRNA splicing ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

typically by binding to messenger RNA (mRNA) and triggering its degradation. The process is exploited by researchers to knock down gene expression in cell culture and in vivo in model organisms.

While there are RNAi products on the marketplace, with Alnylam becoming the first company to get a product approved in 2018, it is difficult to get this class of drug distributed through the brain ...

Maragnore commented: “We have long understood the potential of genetic medicines – which includes modalities such as RNAi, mRNA, gene therapy, and gene editing – to revolutionise the way we ...