Image: Structure of the antitumor compound spliceostatin A (purple and orange) bound to a spliceosome complex (light blue and pink). Credit: Professor Vlad Pena. A team of scientists has created a ...

Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron microscopy structure of the human ...

The Galej Group at EMBL Grenoble has recently published new structural insights into minor spliceosome function in the journal Molecular Cell. Read the full story here .

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

While most spliceosome structures have been characterized in isolation using cryo-electron microscopy (cryo-EM), the connections between spliceosomes and RNAPII during cotranscriptional splicing ...