Yet, sometimes 3'-end processing factors start polyadenylation earlier in the transcript, shortening the mRNA and the subsequent protein. Alternative polyadenylation, along with alternative splicing ...

Notably, motif analyses around PROMPT 3′ ends reveal polyadenylation (pA)-like signals. Mutagenesis studies demonstrate that PROMPT pA signals are functional but linked to RNA degradation.

Alternative polyadenylation in the 3’UTR of the gene leads to the generation of two mRNA isoforms with different lengths. In normal physiological condition, these mRNAs have similar expression ...

PolyA-miner assesses the effect of alternative polyadenylation on gene expression Date: July 23, 2020 Source: Baylor College of Medicine Summary: Meet PolyA-miner, a new computational tool that ...

Minsuh Kim: Investigating the role of Cleavage and Polyadenylation Factor 3 (CPSF3) in migration and invasion of Pancreatic Ductal Adenocarcinoma (PDAC) Join a new and growing lab that seeks to ...

To understand their regulatory principles, we developed expressRNA, a web platform encompassing computational tools for integration of the QuantSeq 3´ mRNA-Seq, iCLIP and RNA motif analyses. This ...

A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for ...

Researchers with an interest in unraveling gene regulation in human health and disease are expanding their horizons by closely looking at alternative polyadenylation (APA), an under-charted ...