EMBO Press8h
HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role ...
EMBO Press8h
Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II
Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...
EMBO Press4d
TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma
TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...
EMBO Press7d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
EMBO Press5d
Beyond mitotic arrest: the diverse effects of microtubule-targeting drugs on tumor vasculature
For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...
EMBO Press11d
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
EMBO Press13d
NIH’s 15% cap: a cost comparison and research outlook
Overnight, leading research institutions in the USA have potentially lost billions of dollars in indirect funding, in a move that will likely change the biomedical research landsc ...
The EMBO Journal3d
Syndecans and glycosaminoglycans influence B-cell development and activation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Syndecans (SDCs) are ...
The EMBO Journal3d
HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...
The EMBO Journal5d
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Immune memory plays a critical role in the ...
The EMBO Journal4d
Soluble CD27 differentially predicts resistance to anti-PD1 alone but not with anti-CTLA-4 in melanoma
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metastatic melanoma can be treated with ...
The EMBO Journal5d
S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lipid transfer proteins mediate the ...