A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

While humans can escape the heat by seeking shade or shedding layers, plants remain rooted in place. So how do they survive ...

While humans can escape the heat by seeking shade or shedding layers, plants remain rooted in place. So how do they survive ...

The spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends ...

Part of the process of translating pre-messenger RNA into mRNA involves cutting out gene segments that don’t contain information relevant to protein synthesis, called introns, and connecting the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

The spliceosome enzyme binds to RNA transcripts at splice sites and removes intron sequences. The crystal structure of a spliceosome subunit shows how the enzyme recognizes one end of the intron ...

The spliceosome and Group II introns are believed to share a common ancestor that was responsible for spreading introns throughout the genome, but while Group II introns can splice themselves out of ...

Spinal muscular atrophy is caused by homozygous mutation of SMN1. There are several potential approaches to tweaking SMN2 messenger RNA, to raise SMN protein levels to therapeutic levels. One such ...

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a ...

In a recent paper, a team of researchers explain how the molecular machine known as the spliceosome begins the process of rearranging gene sequences in RNA splicing.