Cubs-Sox is the second-most closely contested of the interleague series between geographic or historic rivals. The .503 winning percentage of the series-leading Cubs is just behind the .500 of the Athletics and Giants (77-77).

The 12 hits surrendered by Shōta Imanaga were the most in his 43 starts as a Cub. He gave up 11 to the Mets in three innings pitched at Wrigley Field on June 21, 2024. He had not allowed more than seven in his 14 previous starts this year.