It was known that the spliceosome has quality control mechanisms, but the mechanistic details were not understood. For their experiments, the Heidelberg researchers led by BZH director Prof.

Protein phosphatases can be classified into three groups on the basis of sequence, structure and catalytic mechanism ... complex known as the spliceosome. Exons can also be targeted for removal ...

This spliceosome is made up of variety of protein ... The researchers hope their findings will provide a better understanding of the mechanisms that ensure the accuracy of the splicing process.

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Because the chemical mechanism for splicing is very similar ... Now that Ares and his lab have shown that the spliceosome has the catalytic ability to hypothetically place introns back into ...