Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome ...

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP ...

The two-step process of pre-mRNA splicing is catalyzed by the spliceosome, a dynamic macromolecular machine composed of U1, U2, U5 and U4/U6 snRNPs and many non-snRNP splicing factors (reviewed in ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

A gene implicated in dementia, ALS, and other motor neuron disorders appears to cause mis-splicing of messenger RNA by preventing proper spliceosome assembly ...

U1 snRNP interactions in Arabidopsis highlight its dual role in splicing and mRNA regulation, ... The spliceosome is made up of five uridine-rich snRNPs, U1, U2, U4, U5, and U6.

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications. ... Researchers have revealed the ...