Splicing is carried out by a collection of protein–RNA complexes known as snRNPs. The spliceosome contains equal quantities of the U1, U2, U4, U5 and U6 snRNPs, but the U1 snRNP is made in ...

Splicing of a pre-mRNA molecule occurs in several steps that are catalyzed by small nuclear ribonucleoproteins (snRNPs). After the U1 snRNP binds to the 5′ splice site, the 5′ end of the ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago.

These snRNPs play important roles in identifying the splicing signals in genes, removing introns, and ligating exons to produce protein-coding mRNA. The U1 snRNP recognizes the splice site at the ...

Structure of U11 snRNP, one of the subunits of the minor spliceosome. view more . Credit: ... who has been working on pre-mRNA splicing machinery for more than 15 years, ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct ... (PPT) followed by the 3' splice site -- are bound by the splicing factors U1 snRNP, U2 snRNP, and U2AF 65 /U2AF ...

In this new study, the researchers reveal the structure of U11 snRNP ... EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, ...

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing ...

Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been considered to mediate early splicing reaction in all introns of different lengths. However, Dr. Kazuhiro ...

Mechanisms and Regulation of pre-mRNA Splicing. Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, ... Prp19 is a homotetramer complex that promotes ...