In eukaryotes, U1 small nuclear ribonucleoprotein (snRNP) forms spliceosomes in equal stoichiometry with U2, U4, U5 and U6 snRNPs; however, its abundance in human far exceeds that of the other snRNPs.

In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together.

Plants have a sophisticated mechanism for monitoring the production of new proteins. The U1 snRNP complex ensures that the ...

Ceptur’s use of synthetic oligonucleotides that engage U1 snRNP offers the ability to co-opt this master regulator of the transcriptome to regulate mRNA in a highly targeted fashion.

Effects of U1 snRNP reduction (IMAGE) Martin-Luther-Universität Halle-Wittenberg. Caption. After 56 days, the two plants differ even more clearly. Credit. Anchilie Mangilet.