What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

2 Located throughout the pre-mRNA are short, cis-acting motifs consisting of five to six nucleotides that are binding sites for RBP, which act in trans. 1,8 “When an exon that is alternatively spliced ...

They had already identified sequences in the pre-mRNA in the EDA neighborhood necessary for regulated splicing, as well as the SR proteins that bind. Through additional experiments they fleshed ...

By delivering mRNA encoding the correct protein sequence into cells, it is possible to restore the production of functional proteins and alleviate disease symptoms. This approach has shown promise in ...

Discover how scientists developed a COVID-19 vaccine in record time using mRNA technology, leading to improved public health ...

InDevR partners with Aldevron to describe how the VaxArray 5′CapQ assay can be used to measure intact mRNA in a single assay to streamline bioprocess development.

In contrast, in eukaryotic genes, the primary RNA transcript, known as pre-mRNA ... Shine-Dalgarno sequence and the 16S rRNA helps position the ribosome correctly on the mRNA, ensuring accurate ...

2005-2010: Improvements in mRNA synthesis, purification, and stability through chemical modifications and sequence optimization. 2010-2015: Development of lipid nanoparticle delivery systems for ...