(a) Design of an artificial guide RNA (Act-BP-guide) targeting ACT1 pre-mRNA for 2′-O-methylation. Only the guide sequence is shown. Box C, box D and the terminal stem of Act-BP-guide as well as ...

When these pre-mRNA sequences undergo constitutive splicing, the removal of introns is followed by the joining of exons in their DNA-corresponding order. Alternative splicing deviates from this ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced ... (see SF3B-PB, SF3B-SSA, SF3B-SUD). Our structures explain why ...

An mRNA vaccine with coding sequences for the pre-fusion protein of RSV is in phase 3 trials for approval for vaccination in patients aged 60 years and older. It shows high effectiveness even in ...

As scientists develop and manufacture novel mRNA therapeutics, they must find technologies that help analyze their drug products on a large scale. Direct mRNA sequence mapping with mass spectrometry ...

Around 1 in 25 women develop pre-eclampsia during their first pregnancy, which can lead to serious consequences.Globally, pre-eclampsia is estimated to kill 75,000 women and 500,000 infants each ...