the linkers are broken and the particles disintegrate for delivery of contents and translation of mRNA into active enzyme for CRISPR/Cas9 genome editing Disclaimer: AAAS and EurekAlert!

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Researchers have succeeded for the first time in ...

In a recent article, he showed that when genes are preferentially positioned near speckles, mRNA splicing is significantly more efficient ... along with CRISPR-associated protein 9 gene-editing ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...