What's the difference between mRNA and pre-mRNA ... because nearly all eukaryotes have introns and share mechanisms of RNA splicing, splicing itself must be quite ancient. Proponents of the ...

Mechanisms of alternative splicing regulation ... Cell signalling and the control of pre-mRNA splicing. Nature Reviews Molecular Cell Biology 5, 727–738 (2004) doi:10.1038/nrm1467.

A team of researchers has identified a mechanism that regulates the production of two different proteins from the same gene.

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

A team of researchers from the Institute for Neurosciences, a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche, in collaboration with ...

is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Faulty functioning of a spliceosome can lead to a ...

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins. Each mRNA transcript ...

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...

RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO ... pathways involving the repair of tRNA breaks (during tRNA splicing) and mRNA breaks (during the ...

The mechanisms and physiological consequences of alternative ... transitions via alternative splicing do not show substantial changes in mRNA levels indicating that alternative splicing produces ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...