Natural "off switch" could slow or even reverse the growth of aggressive tumors.

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the phosphodiester bond at the 3′ splice site. The adjoining exons are covalently bound ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Scientists reveal how cancer cells manipulate RNA splicing, increasing tumor growth. A new study introduces antisense ...

Alternative splicing adds an extra layer of complexity, because regulatory sequences that sometimes designate an exon's inclusion into the mature mRNA dictate the exclusion of that exon under ...

Breakthrough discovery in cancer research! Scientists uncover a simple genetic strategy to combat aggressive cancers. Learn ...

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...

A pioneering study has uncovered the sophisticated tactics root-knot nematodes use to manipulate the genetic machinery of ...

Investigators in the laboratory of Gemma Carvill, Ph.D., assistant professor in the Ken and Ruth Davee Department of Neurology Division of Epilepsy/Clinical Neurophysiology, have discovered novel ...

Scientists from The Jackson Laboratory and UConn Health found that cancer cells disrupt poison exons, leading to tumor growth ...