The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps")—and about 150 proteins, involved in different stages of ...

The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, but until now, ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes -- more than nine in ten ...

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA. A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after ...

Romancing the Spliceosome to Fight Spinal Muscular Atrophy. Author: Kathryn J. Swoboda, M.D. Author Info & Affiliations. Published October 30, 2014. N Engl J Med 2014; 371: 1752-1754.

How this system of broken genes and the spliceosome evolved in our genomes is not known. Over his long career, Manuel Ares, UC Santa Cruz distinguished professor of molecular, cellular, and ...

Spliceosome assembly in yeast extracts also could occur by interaction of the U1 snRNP with the pre-mRNA, followed by a tetra-snRNP joining to form a functionally identical particle. (Reprinted with ...