Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often distinguishing between cell types more accurately than gene expression. 1 During ...

Alternative splicing can generate a proteome that is ... Most of the features were based on oligomeric sequences discovered in various types of experiments—for example, sets of predicted and ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing.

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

A team of researchers has identified a mechanism that regulates the production of two different proteins from the same gene.

This process, called alternative RNA splicing, fine-tunes how proteins function ... with poor outcomes in many different cancer types, and especially in aggressive and difficult-to-treat cancers ...

This gene has alternative splicing (cutting and splicing of genetic ... Some proteins are common to several types of cilia ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

We also investigate the pathogenic mechanisms of myotonic dystrophy, type 1 (DM1), an autosomal dominant neuromuscular ... of developmentally regulated RNA processing, primarily alternative splicing, ...

pre-mRNA processing directs expression of functionally divergent protein isoforms according to cell-specific regulation based on differentiated cell type, developmental stage, gender, or in response ...