Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often distinguishing between cell types more accurately than gene expression. 1 During ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing.

Alternative splicing can generate a proteome that is ... Most of the features were based on oligomeric sequences discovered in various types of experiments—for example, sets of predicted and ...

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Scientists from The Jackson Laboratory and UConn Health found that cancer cells disrupt poison exons, leading to tumor growth ...

pre-mRNA processing directs expression of functionally divergent protein isoforms according to cell-specific regulation based on differentiated cell type, developmental stage, gender, or in response ...

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...