RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...
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Analyzing diversity of reverse-transcriptase-containing viruses through global metagenomicsMore information: Kaiyang Zheng et al, Diversity of reverse-transcriptase-containing viruses through global metagenomics, hLife (2024). DOI: 10.1016/j.hlife.2024.10.002 Provided by Tsinghua University ...
Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...
It is an ester-derived prodrug that is converted in vivo by serum and tissue esterases to tenofovir, an acyclic nucleoside phosphonate (nucleotide) that inhibits HIV reverse transcriptase.
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