Its long-separated twin—the minor spliceosome, is much more scarce and remains enigmatic, even though its function is equally important. In this study, the researchers reveal the structure of ...

Its long-separated twin – the minor spliceosome, is much more scarce and remains enigmatic, even though its function is equally important. In this new study, the researchers reveal the structure of ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

This process is controlled by a large protein-RNA complex called the spliceosome. MIT biologists have now discovered a new layer of regulation that helps to determine which sites on the messenger ...