Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA—a prerequisite for protein synthesis in the cell. The poorly ...

Before protein synthesis can proceed, noncoding regions (introns) of mRNA must be removed and the coding regions (exons) joined together. Sign up for C&EN's must-read weekly newsletter Email Address * ...

Protein synthesis in nerve cell dendrites underlies long-term memory formation in the brain, among other functions. Knowing how proteins are made to order at the synapse can help researchers ...

If pseudo splice sites are used instead of the correct splice sites during protein synthesis, the resulting mRNA will contain the wrong instructions – cryptic splicing – that could alter ...

Because an increase in TFIIIA protein upregulates synthesis of 5S rRNA 23, the discovery of P5SM shows that ribosomal protein L5 can directly control the production of its partner, 5S rRNA.

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, ... – which is used as a template for protein synthesis in cells ...

Disparate fields have provided advances in our understanding of the impact of protein-synthesis errors on cellular fitness, disease and evolution. Although organisms show adaptations to minimize ...

When the genetic code is transcribed into RNA for protein synthesis, alternative splicing can lead to the production of different transcripts from the same gene, depending on the selected genetic ...

Although we have long known that this signal strongly inhibits protein synthesis in general, during hemoglobin gene expression it first plays its indispensable, positive role before being turned ...

This study entailed the integration of multiple-omics datasets to examine the dysregulation in the host splicing mechanism and alteration in protein isoforms among COVID-19 patients.