A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

RBP splicing factors are sequence-specific ... The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus ...

"The spliceosome is composed of multiple components ... Some highly aggressive tumors produce large amounts of USP39 and related splicing factors, likely due to their high division rate.

Shown is the splicing pathway. The pre-messenger RNA (pre-mRNA) has exons (blue) and introns (pink). The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

“The reason for their highest concentration of splicing factors is very much like the same reason that ... you get a dramatic decrease in heat transfer.” Similarly, for the spliceosome-emitting ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases. Researchers at ...