A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Unleashing splicing to understand biology and eventually tackle ‘untreatable’ diseases Cells use editing tools to skip or rearrange information stored in DNA.

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning, have substantially deepened our understanding of RNA splicing.

Q: What role does alternative splicing play in molecular biology? Alternative splicing greatly expands the diversity of the proteins that can be made from a single gene.

Alternative splicing has been proposed as a key contributor to the genetic diversity observed in prostate tumors. Here, the authors focus on the clinically relevant consequences of alternative ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.

Discovered in the 1970s, the mechanisms of RNA splicing have been well characterized through numerous studies in eukaryotic and prokaryotic systems. In this article, we describe the mechanisms of ...

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...