Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

professor of biology, shows that these nuclear bodies can act like miniature factories to enable efficient production of mRNA. mRNA splicing is a fundamental part of the process that occurs when ...

Chen, M. & Manley, J. L. Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches. Nature Reviews Molecular Cell Biology 10, 741–754 (2009) doi:10.1038/nrm2777.

Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global impact on cellular homeostasis and intricate molecular mechanisms remains ...

Their study is published in Genome Biology. "Precisely identifying splicing sites is key to understanding how cells interpret genetic instructions," says co-lead author Kuan-Hao Chao, a doctoral ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

In the Cheng lab, we strive to understand the fundamental questions of how RNA regulation controls cellular processes in normal biology and in the context of cancer. Working at the interface of RNA ...