What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

Chen, M. & Manley, J. L. Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches. Nature Reviews Molecular Cell Biology 10, 741–754 (2009) doi:10.1038/nrm2777.

Overriding the "Off Switch" Cells function through an intricate network of proteins, each designed for specific tasks like ...

Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global impact on cellular homeostasis and intricate molecular mechanisms remains ...

Christopher Burge, the Uncas and Helen Whitaker Professor of Biology at MIT, is the senior author of the study, which appears today in Nature Communications. RNA splicing, a process discovered in ...

In the Cheng lab, we strive to understand the fundamental questions of how RNA regulation controls cellular processes in normal biology and in the context of cancer. Working at the interface of RNA ...